i
Report an error   
Advanced Search


Potentially new drug action against Methicillin-Resistant Staphylococcus aureus (MRSA) via iterative threading assembly refinement and Hex Protein Docking.

Author

Jose Mari Barrios III,
Maxine O. Caindec,
Alyssa Dawn C. Ditucalan,
Alfil Romulo P. Estrera,
Sharmaine Josh O. Li,
Ralph Pearvin G. Mission,
Ian M. Puebla,
Caryl Ann A. Rabanos,
Mico D. Rosatase,
Keejina G. Samsuya

Related Institution

School of Medicine - University of Cebu - Banilad Campus - University of Cebu

Publication Information

Publication Type
Thesis/Dissertations
Thesis Degree
MD
Specialization
Medicine
Publication Date
June 2018

Abstract

INTRODUCTION: Methicillin-resistant staphylococcus aureus is a growing concern in the pharmaceutical endeavors. The study suggests taking advantage of bioinformatics to predict possible new drug actions on the MRSA.


METHODS: Theoretical approach using previously submitted genome sequence of plants and MRSA were collected and analyzed using both I-TASSER for homology characterization and HEX protein docking- protein interaction.


RESULTS: 3 plant proteins have shown stable protein- protein configuration with the MRSA trans membrane proteins as qualified by the various HEX docking parameters.


CONCLUSION: Bioinformatics can be used to determine potential drug actions in terms of protein-protein interactions.

References

1. Enright, M C, Robinson, D A, Randle, G , Feil, E J, Grundmann, H , Spratt, B G. The evolutionary history of methicillin-resistant staphylococcus aureus (MRSA). 2002.
2. Jacobson, M , Sali, A . Comparative protein structure modeling and its applications to drug discovery. 2004.
3. Yang, J , Zhang, Y , I-tasser, T . I-TASSER server: new development for protein structure and function predictions. 2015. 174-181.
4. Madden, T . The blast sequence analysis tool. 2013.
5. Edwards, D J, Holt, K E. Beginner. Microb Inf Exp, 2013.
6. Stephen, Altschul F, Warren, Gish , Webb, Miller . "BLAST" Journal of Molecular Biology , 2007
7. Hansmann, UHE , Okamotot, Y . "New monte carlo algorithns for protein folding" ,
8. Duvicks, J P, Rood, T , Rao, A G, Marshakg, R . "Purification and characterization of a novel antimicrobial peptide from Maize (Zea mays L.)" Kernels 267(26): 18814-20, 1992
9. Umar, M , Zubairu, A , Hamisu, H , Mohammed, I , Oko, J , Abdulkarim, I , Salisu, A , A Yaya, A , A Aliko, A . "Eveluation of Phytochemical and in vitro antimicrobial effects of solanum lycopersicum Linn" Journal of advances in medical and pharmaceutical Science , 1-931456, 2017
10. Nancy, I , Est, G . "Protein Docking use spherical polar fouries correlations" , 2013

Physical Location

LocationLocation CodeAvailable FormatAvailability
University of Cebu - School of Medicine T/Ba27po/2018c.1 Abstract Print Format

 
Loading…
©2021 HERDIN PLUS. All rights reserved.